Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts.
Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts.
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DOI：
10.1038/sj.bjc.6605011
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发表时间：
2009-04-21
影响因子：
8.8
通讯作者：
Perheentupa, A.
中科院分区：
文献类型：
--
作者：
Huhtinen, K.;Suvitie, P.;Hiissa, J.;Junnila, J.;Huvila, J.;Kujari, H.;Setala, M.;Harkki, P.;Jalkanen, J.;Fraser, J.;Makinen, J.;Auranen, A.;Poutanen, M.;Perheentupa, A.
人附睾分泌蛋白E4（HE4，也称为WAP四硫核心结构域蛋白2）是一种新的卵巢癌生物标志物，但其对卵巢上皮性囊肿的特异性尚不清楚。因此，我们分析了血清HE4浓度与肿瘤标志物CA125在血清样本的妇女诊断为各种类型的子宫内膜异位症，子宫内膜癌或卵巢癌，并从健康对照组的样本。与健康对照组（40.5pM）相比，在患有子宫内膜癌（99.2pM，P<0.001）和卵巢癌（1125.4pM，P<0.001）的患者的血清样品中HE4的平均血清浓度显著更高，但没有患有卵巢腺瘤（46.0pM）或其他类型的子宫内膜异位症（45.5pM）。卵巢癌、晚期子宫内膜异位症伴腹膜或深部病变、卵巢腺瘤患者血清CA 125浓度升高，而子宫内膜癌患者血清CA 125浓度未升高。基因芯片结果显示HE4和CA125基因的mRNA表达水平反映了血清蛋白浓度。总的来说，测量HE4和CA125血清浓度增加了卵巢癌诊断的准确性，并提供了有价值的信息，以区分卵巢肿瘤和卵巢囊肿。
Human epididymal secretory protein E4 (HE4, also known as WAP four-disulphide core domain protein 2) is a new promising biomarker for ovarian cancer but its specificity against ovarian endometriotic cysts is only superficially known. We, thus, analysed serum HE4 concentrations together with a tumour marker CA125 in serum samples of women diagnosed with various types of endometriosis, endometrial cancer or ovarian cancer, and in samples from healthy controls. The mean serum concentration of HE4 was significantly higher in serum samples of patients with both endometrial (99.2 pM, P<0.001) and ovarian (1125.4 pM, P<0.001) cancer but not with ovarian endometriomas (46.0 pM) or other types of endometriosis (45.5 pM) as compared with healthy controls (40.5 pM). The serum CA125 concentrations were elevated in patients with ovarian cancer, advanced endometriosis with peritoneal or deep lesions, or ovarian endometriomas, but not in the patients with endometrial cancer. The microarray results revealed that the mRNA expression of the genes encoding HE4 and CA125 reflected the serum protein concentrations. Taken together, measuring both HE4 and CA125 serum concentrations increases the accuracy of ovarian cancer diagnosis and provides valuable information to discriminate ovarian tumours from ovarian endometriotic cysts.
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作者：
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