Nerve growth factor induces airway hyperresponsiveness in mice
Nerve growth factor induces airway hyperresponsiveness in mice
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DOI：
10.1159/000053711
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发表时间：
2001-01-01
影响因子：
2.8
通讯作者：
Renz, H
中科院分区：
文献类型：
--
作者：
Braun, A;Quarcoo, D;Renz, H
背景：先前的研究表明，过敏性炎症时神经生长因子(NGF)的产生上调。然而，目前对NGF在肺部的功能知之甚少。提示NGF在气道高反应性的病理生理过程中可能起重要作用。免疫事件和改变的神经元对气道平滑肌收缩的控制之间的调节网络仍有待确定。方法：通过鼻腔滴注或基因工程的方法将NGF导入小鼠的呼吸道。然后用电场刺激法测定气道反应性。结果：NGF治疗小鼠的呼吸道高反应性与过敏原致敏的小鼠相似。与野生型小鼠相比，在Clara细胞中过度表达NGF的NGF转基因小鼠具有高反应性。结论：这些数据表明，NGF本身决定了在没有呼吸道炎症的情况下诱导小鼠的气道高反应性。版权所有(C)2001 S.Karger AG。巴塞尔。
Background: Previous studies indicated an upregulation of nerve growth factor (NGF) production during allergic inflammation. However, the function of NGF in the lungs is currently poorly understood. It was suggested that NGF could play an important role in the pathophysiology of airway hyperresponsiveness. The regulatory network between immunological events and altered neuronal control of airway smooth muscle contractility remains to be defined. Methods: NGF was delivered into the airways of mice either by nasal instillation or by genetic engineering. Airway reactivity was then measured by electrical field stimulation. Results: Treatment of mice with NGF induced airway hyperresponsiveness to a similar extent as demonstrated in allergen-sensitized mice. NGF-transgenic mice, overexpressing NGF in Clara cells, were hyperreactive in comparison to wild-type mice. Conclusion: These data suggest that NGF by itself determines the induction of airway hyperresponsiveness in the absence of airway inflammation in mice. Copyright (C) 2001 S. Karger AG. Basel.