Bioluminescence tomography based on the phase approximation model.
Bioluminescence tomography based on the phase approximation model.
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DOI：
10.1364/josaa.27.000174
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发表时间：
2010-02-01
期刊：
影响因子：
--
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Cong W;Wang G
提出了一种基于相位近似模型的生物发光光源重建方法。与漫射近似相比，该相位近似模型更准确地预测了生物发光光子在生物组织中的传播，从而使生物发光层析成像能够准确地定位和量化生物发光源的分布。压缩感知（CS）技术被应用到正则化的逆源重建，以提高数值稳定性和效率。数值仿真和体模实验验证了该方法的可行性。
A reconstruction method of bioluminescence sources is proposed based on a phase approximation model. Compared with the diffuse approximation, this phase approximation model more correctly predicts bioluminescence photon propagation in biological tissues, so that bioluminescence tomography can accurately locate and quantify the distribution of bioluminescence sources. The compressive sensing (CS) technique is applied to regularize the inverse source reconstruction to enhance numerical stability and efficiency. The numerical simulation and phantom experiments demonstrate the feasibility of the proposed approach.