Nestin+ cells and healing the infarcted heart
Nestin+ cells and healing the infarcted heart
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DOI：
10.1152/ajpheart.00716.2011
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发表时间：
2012-01-01
影响因子：
4.8
通讯作者：
Calderone, Angelino
中科院分区：
文献类型：
--
作者：
Calderone, Angelino
Calderone A.Nestin(+)细胞和修复梗塞的心脏。Am J Physiol心圈Physiol 302：H1-H9,2012。2011年10月14日首次出版；DOI：10.1152/ajpheart.00716.2011。-心脏缺血性损伤后形成的疤痕被称为修复性纤维化，代表着修复受损心肌的必要生理反应。修复性纤维化的生物学事件包括炎症、肌成纤维细胞的胶原沉积、交感神经支配和血管生成。一些研究进一步报道，瘢痕的形成与神经沟来源的心脏常驻细胞巢蛋白(+)细胞的招募有关，这些细胞表现出与神经前体/干细胞表型一致的特征。在修复性纤维化反应中，这些巢蛋白(+)细胞参与神经重塑，并代表一种新的血管生成的细胞底物。此外，在正常心脏中发现的巢蛋白(+)细胞亚群表达心脏祖细胞转录因子，并可能直接促进缺血损伤后的心肌再生。在瘢痕新生血管内皮细胞中也检测到Nestin蛋白，可能是血管重建的标志。最后，在平滑肌α-肌动蛋白(+)瘢痕来源的肌成纤维细胞亚群中诱导了巢蛋白，中间丝蛋白的表达可能提供了增殖优势。总而言之，这些数据表明，不同群体的巢蛋白(+)细胞参与心脏创伤的修复。
Calderone A. Nestin(+) cells and healing the infarcted heart. Am J Physiol Heart Circ Physiol 302: H1-H9, 2012. First published October 14, 2011; doi:10.1152/ajpheart.00716.2011.-Scar formation following an ischemic insult to the heart is referred to as reparative fibrosis and represents an essential physiological response to heal the damaged myocardium. The biological events of reparative fibrosis include inflammation, the deposition of collagen by myofibroblasts, sympathetic innervation, and angiogenesis. Several studies have further reported that scar formation was associated with the recruitment of neural crest-derived cardiac resident nestin(+) cells that display characteristics consistent with a neural progenitor/stem cell phenotype. During the reparative fibrotic response, these nestin(+) cells participate in neural remodeling and represent a novel cellular substrate of angiogenesis. In addition, a subpopulation of nestin(+) cells identified in the normal heart expressed cardiac progenitor transcriptional factors and may directly contribute to myocardial regeneration following ischemic damage. Nestin protein was also detected in endothelial cells of newly formed blood vessels in the scar and may represent a marker of revascularization. Lastly, nestin was induced in a subpopulation of smooth muscle alpha-actin(+) scar-derived myofibroblasts, and the expression of the intermediate filament protein may provide a proliferative advantage. Collectively, these data demonstrate that diverse populations of nestin(+) cells participate in cardiac wound healing.