NOTCH IS REQUIRED FOR SUCCESSIVE CELL DECISIONS IN THE DEVELOPING DROSOPHILA RETINA
NOTCH IS REQUIRED FOR SUCCESSIVE CELL DECISIONS IN THE DEVELOPING DROSOPHILA RETINA
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DOI：
10.1101/gad.3.8.1099
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发表时间：
1989-08-01
影响因子：
10.5
通讯作者：
READY, DF
中科院分区：
文献类型：
--
作者：
CAGAN, RL;READY, DF
Notch基因座的突变影响果蝇的多种发育决策。在本文中，我们研究了Notch在视网膜发育中的作用。我们在视网膜发育过程中连续降低了notch的活性，然后检查了对单个细胞的影响。当Notch活性降低时，细胞通过选择不适当的发育途径做出反应。我们发现所有细胞类型在确定其命运时似乎都需要Notch。为了进一步研究Notch在眼睛发育中的作用，我们检测了Notch-split和facet-glossy的两个等位基因。split果蝇在光感受器的初始聚集中显示出缺陷，而facet-glossy果蝇的缺陷是由于假定的初级色素细胞错误地进入次级色素细胞通路。我们的研究结果表明，Notch在用于组装眼睛的细胞-细胞相互作用中起着允许的作用。
Mutations in the Notch locus affect a variety of developmental decisions in Drosophila. In this paper, we examine the role of Notch in the developing retina. We reduced notch activity at successive intervals during development of the retina, and then examined the effect on individual cells. When Notch activity was reduced, cells responded by selecting inappropriate developmental pathways. We found that all cell types appear to require Notch when establishing their fate. To examine further Notch''s role in eye development, we examined two alleles of Notch-split and facet-glossy.split flies show defects in the initial clustering of photoreceptors, whereas the defects in facet-glossy flies are due to the misrouting of presumptive primary pigment cells into the secondary pigment cell pathway. Our results suggest that Notch plays a permissive role in the cell-cell interactions used to assemble the eye.