Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease
Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease
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DOI：
10.3109/00016480802593513
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发表时间：
2009-11-01
影响因子：
1.4
通讯作者：
Usami, Shin-ichi
中科院分区：
文献类型：
--
作者：
Miyagawa, Maiko;Fukuoka, Hisakuni;Usami, Shin-ichi
53岁男性，波动性低频感音神经性听力损失和耳鸣，但无眩晕，在异山梨酯给药前后通过鼓室内注射钆基造影剂（GBCA）获得MRI评估。用3.0-T MR扫描仪半定量评估内淋巴水肿。为了量化，我们计算了患侧/对侧的比例。在异山梨酯治疗后，患侧内淋巴周围gadodiamide（一种GBCA）增强的间隙由0.50的比率（可能代表内淋巴水肿）改善到0.98的比率。因此，一名“典型”梅尼埃病（MD）患者出现了内淋巴积液，这表明至少一些非典型MD可能与NM具有相似的病因，因此可能是NM的连续体。此外，治疗效果可以通过MRI可视化。因此，基于mri的md相关疾病的诊断将是一个强大的工具，不仅因为它的准确性，而且它对治疗评估的有用性。
A 53-year-old male with fluctuating low frequency sensorineural hearing loss and tinnitus, but without vertigo, was evaluated by MRI obtained by intratympanic injection of a gadolinium-based contrast agent (GBCA) before and after the administration of isosorbide. The endolymphatic hydrops was semi-quantitatively evaluated by a 3.0-T MR scanner. For quantification, the affected side/contralateral side ratios were calculated. A gadodiamide (a kind of GBCA)-enhanced space surrounding the endolymph in the affected side with a 0.50 ratio (which may have represented endolymphatic hydrops) improved after isosorbide therapy to a 0.98 ratio. Thus, endolymphatic hydrops was demonstrated in a patient with 'a typical' Meniere's disease (MD), suggesting that at least some atypical MD may share similar etiology with, and therefore be a continuum of, NM. Also, therapeutic effects could be visualized by using MRI. Therefore, MRI-based diagnosis of MD-related disease will be a powerful tool not only because of its precision but also its usefulness for therapeutic evaluation.