A Grim link: the association between subclinical atherosclerosis and epigenetic age.
A Grim link: the association between subclinical atherosclerosis and epigenetic age.
复制标题
严峻的联系：亚临床动脉粥样硬化与表观遗传年龄之间的关联。
DOI：
10.1093/eurheartj/ehad326
复制
发表时间：
2023
影响因子：
39.3
通讯作者：
Lee,RichardT
中科院分区：
文献类型：
--
作者：
Velayutham,Nivedhitha;Lee,RichardT
动脉粥样硬化和许多其他心血管疾病与年龄密切相关，实际年龄是心脏病的主要危险因素。 1, 2 动脉粥样硬化斑块会随着年龄的增长而在原本健康的个体中积累，多年来在临床上一直保持沉默，称为亚临床动脉粥样硬化 (SA)。 3 SA 的患病率最高的是中年人。了解衰老和 SA 发病机制之间的相互作用以及揭示 SA 的早期生物标志物非常重要，因为初始症状的临床表现可能是致命的。具有相同实际年龄的个体之间的生物衰老似乎以不同的速度进行，衰老的生理和功能特征存在显着差异。 4 表观遗传参数（例如 DNA 甲基化模式）在相同年龄的个体之间存在显着差异，并且明显与人类衰老相关。 4, 5 对表观遗传变化动态景观的严格研究已经建立了“表观遗传时钟”，它可以提供个体的生物年龄与实际年龄，从而预测健康和寿命。此外，表观遗传年龄加速（EAA）定义了表观遗传年龄和实际年龄之间的差异，并且与人类健康、疾病和衰老的许多变量密切相关。 5 心血管疾病与 EAA 之间的新关联凸显了 EAA 作为心血管疾病生物标志物的潜在用途。 6
Atherosclerosis and many other cardiovascular diseases are very age dependent, with chronological age a major risk factor for cardiac disease. 1, 2 Atherosclerotic plaques can accumulate in otherwise healthy individuals with age, remaining clinically silent for years as subclinical atherosclerosis (SA). 3 The highest prevalence of SA is in middle-aged individuals. Understanding the interplay of ageing and pathogenesis of SA and uncovering early biomarkers of SA are important, as clinical manifestation of initial symptoms can be lethal. Biological ageing seems to progress at different rates amongst individuals with the same chronological age, with significant variation in physiological and functional hallmarks of ageing. 4 Epigenetic parameters such as DNA methylation patterns vary significantly between individuals of the same chronological age and are demonstrably linked to human ageing. 4, 5 Rigorous study of the dynamic landscape of epigenetic changes has established ‘epigenetic clocks’, which can provide biological vs. chronological age of an individual, and thus a prediction of health and life span. Further, epigenetic age acceleration (EAA) defines the difference between epigenetic age and chronological age, and is strongly associated with many variables of health, disease, and ageing in humans. 5 The emerging association between cardiovascular diseases and EAA highlights the potential usefulness of EAA as a biomarker of cardiovascular disease. 6