Metal-catalysed 1,2-diamination reactions
Metal-catalysed 1,2-diamination reactions
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DOI：
10.1038/nchem.256
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发表时间：
2009-07-01
期刊：
影响因子：
21.8
通讯作者：
Goti, Andrea
中科院分区：
文献类型：
--
作者：
Cardona, Francesca;Goti, Andrea
1，2-二胺基序存在于许多具有有趣的生物活性的天然产物和许多重要的药物制剂中。手性1，2-二胺也被广泛用作不对称合成和催化中的控制元素。因此，这些化合物是合成化学家的一个有吸引力的目标。虽然烯烃的二胺化似乎是获得这些结构的明显途径，但对它的研究远少于对类似的二羟基化或氨羟基化反应的研究，这些反应是不对称合成中公认的方法。在这里，我们研究了金属催化二胺化反应及其不对称变体的最新进展。鉴于这些结构的普遍性，在不久的将来，它们可能会在天然产物和药物分子的构建中得到广泛的应用。
The 1,2-diamine motif is present in a number of natural products with interesting biological activity and in many important pharmaceutical agents. Chiral 1,2-diamines are also widely used as the control elements in asymmetric synthesis and catalysis. Such compounds are thus an attractive target for the synthetic chemist. Although the diamination of an alkene seems an obvious route to these structures, far less research has been devoted to it than to the analogous dihydroxylation or aminohydroxylation reactions that are well-established processes in asymmetric synthesis. Here, we examine recent advances in metal-catalysed diamination reactions and their asymmetric variants. Given the prevalence of these structures, it seems likely that they will find extensive application in the construction of natural products and drug molecules in the near future.