Fucosyl-GM1 in human sensory nervous tissue is a target antigen in patients with autoimmune neuropathies.
Fucosyl-GM1 in human sensory nervous tissue is a target antigen in patients with autoimmune neuropathies.
复制标题
人类感觉神经组织中的岩藻糖基-GM1 是自身免疫性神经病患者的靶抗原。
DOI：
10.1111/j.1471-4159.1993.tb02170.x
复制
发表时间：
1993
影响因子：
4.7
通讯作者：
Yu,RK
中科院分区：
文献类型：
--
作者：
Yoshino,H;Ariga,T;Latov,N;Miyatake,T;Kushi,Y;Kasama,T;Handa,S;Yu,RK
人类神经组织中的几种神经节苷脂已被报道是自身免疫性神经病的潜在靶抗原。为了解释抗神经节苷脂抗体患者临床症状的多样性，我们寻找了对单个神经组织（如运动神经元、外周运动神经和感觉神经）具有特异性的神经节苷脂抗原。虽然主要的神经节苷脂成分在人类外周运动神经和感觉神经中没有差异，但发现岩藻糖基-GM 1在感觉神经组织中表达，而在脊髓、运动神经和交感神经节中不表达。几名感觉神经受累患者的血清也与岩藻糖基-GM 1和GM 1反应。因此，岩藻糖基-GM 1可能是某些自身免疫性神经病患者出现感觉症状的靶抗原。
Several gangliosides of human nervous tissues have been reported to be potential target antigens in autoimmune neuropathies. To explain the diversity of clinical symptoms in patients with antiganglioside antibodies, we have searched for ganglioside antigens that are specific to individual nervous tissues such as motoneurons, peripheral motor nerves, and sensory nerves. Although the major ganglioside compositions were not different among human peripheral motor and sensory nerves, fucosyl‐GM1 was found to be expressed in sensory nervous tissue but not in spinal cord, motor nerve, and sympathetic ganglia. Sera from several patients with sensory nerve involvement also reacted with fucosyl‐GM1 as well as GM1. Thus, fucosyl‐GM1 may be a responsible target antigen for developing sensory symptoms in some patients with autoimmune neuropathies.