SPIROCHETOSIS OF THE HUMAN RECTUM ASSOCIATED WITH AN INTRAEPITHELIAL MAST-CELL AND IGE PLASMA-CELL RESPONSE
SPIROCHETOSIS OF THE HUMAN RECTUM ASSOCIATED WITH AN INTRAEPITHELIAL MAST-CELL AND IGE PLASMA-CELL RESPONSE
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DOI：
10.1136/gut.28.5.588
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发表时间：
1987-05-01
期刊：
影响因子：
24.5
通讯作者：
JEWELL, DP
中科院分区：
文献类型：
--
作者：
GEBBERS, JO;FERGUSON, DJP;JEWELL, DP
在两名患者表现为轻度肠道症状，直肠螺旋体病是唯一的形态学异常诊断的光学显微镜。使用电子显微镜和免疫组织化学的形态学变化的重新评价显示出某些不寻常的功能：在上皮细胞和上皮下巨噬细胞内观察到微生物;有许多部分脱颗粒的上皮内肥大细胞;和有一个显着增加的比例IgE浆细胞内的固有层。这种不寻常的免疫反应可能是由微生物的粘液渗透引起的。在一名患者中，抗生素治疗消除了螺旋体，并导致临床改善。在结肠中，螺旋体不应总是被认为是无害的寄生虫。
In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within epithelial cells and in subepithelial macrophages; there were numerous partially degranulated intraepithelial mast cells; and there was a marked increase in the proportion of IgE plasma cells within the lamina propria. Mucosal penetration by the organisms may be responsible for the unusual immune response. In one patient, treatment with antibiotics eliminated the spirochaetes and resulted in a clinical improvement. Spirochaetes should not always be considered as harmless commensals in the colon.