Increased Dietary Inflammatory Index (DII) Is Associated With Increased Risk of Prostate Cancer in Jamaican Men.
Increased Dietary Inflammatory Index (DII) Is Associated With Increased Risk of Prostate Cancer in Jamaican Men.
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DOI：
10.1080/01635581.2015.1062117
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hébert JR
中科院分区：
文献类型：
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作者：
Shivappa N;Jackson MD;Bennett F;Hébert JR
前列腺癌是最常见的非皮肤恶性肿瘤；它是牙买加男性癌症死亡人数最多的原因。饮食与前列腺癌的病因有关，包括其对炎症的影响。在一项针对40-80岁牙买加男性的病例对照研究中，我们研究了新发现的饮食炎症指数（DII）与前列腺癌之间的关系。2005年3月至2007年7月期间，共有229例病例和250例对照患者在牙买加首都金斯敦的2家大医院和私人医生的同一泌尿科门诊就诊。DII是根据膳食摄入量计算的，使用先前验证的食物频率问卷（FFQ）进行评估，该问卷扩展到评估牙买加人群的饮食和癌症。使用多变量逻辑回归来估计优势比，其中DII为连续的，并以四分位数表示。Logistic回归分析调整了年龄、总能量摄入、教育程度、身体质量指数（BMI）、吸烟状况、体育活动和前列腺癌家族史等因素。处于DII最高四分位数的男性患前列腺癌的风险更高[优势比(OR) = 2.39；95%可信区间(CI) = 1.14-5.04 (Ptrend = 0.08)]与最低DII四分位数的男性相比。这些数据表明，促炎饮食，如增加DII评分所示，可能是牙买加男性前列腺癌的一个危险因素。
Prostate cancer is the most common non-skin malignancy; and it accounts for the most cancer deaths among Jamaican males. Diet has been implicated in the etiology of prostate cancer, including through its effects on inflammation. We examined the association between a newly developed dietary inflammatory index (DII) and prostate cancer in a case-control study of 40-80 year-old Jamaican males. A total of 229 incident cases and 250 controls attended the same urology out-patient clinics at 2 major hospitals and private practitioners in the Kingston, Jamaica Metropolitan area between March 2005 and July 2007. The DII was computed based on dietary intake assessed using a previously validated food frequency questionnaire (FFQ) that was expanded to assess diet and cancer in this Jamaican population. Multivariable logistic regression was used to estimate odds ratios, with DII as continuous and expressed as quartiles. Logistic regression analysis adjusted for age, total energy intake, education, body mass index (BMI), smoking status, physical activity and family history of prostate cancer. Men in the highest quartile of the DII were at higher risk of prostate cancer [odds ratio (OR) = 2.39; 95% confidence interval (CI) =1.14–5.04 (Ptrend = 0.08)] compared to men in the lowest DII quartile. These data suggest a pro-inflammatory diet, as indicated by increasing DII score, may be a risk factor for prostate cancer in Jamaican men.