The mechanics of heterotypic cell aggregates: Insights from computer simulations
The mechanics of heterotypic cell aggregates: Insights from computer simulations
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DOI：
10.1115/1.1288205
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发表时间：
2000-08-01
影响因子：
1.7
通讯作者：
Chen, HH
中科院分区：
文献类型：
--
作者：
Brodland, GW;Chen, HH
基于有限元的计算机模拟被用来研究异型细胞聚集体表现出的许多现象，包括组织吞噬细胞分类和棋盘图案形成。模拟表明，这些现象可能不是由细胞骨架组件和细胞-细胞粘连引起的单一等效力，即表面(或界面)张力驱动的。他们还揭示了组织吞噬、细胞分选和棋盘图案的形成涉及几个可辨别的机械特征或阶段。借助分析论证，我们确定了每一种现象产生的必要条件。这些发现与之前的实验研究和计算机模拟一致，但对当前的细胞分选和组织吞噬理论构成了重大挑战。[S0148-0731(00)01304-2]。
Finite element-based computer simulations are used to investigate a number of phenomena, including tissue engulfment cell sorting and checkerboard-pattern formation, exhibited by heterotypic cell aggregates. The simulations show that these phenomena cart be driven by a single equivalent force, namely a surface (or interfacial) tension, that results from cytoskeletal components and cell-cell adhesions. They also reveal that tissue engulfment, cell sorting, and checkerboard-pattern formation involve several discernible mechanical features or stages. With the aid of analytical arguments, we identify the conditions necessary for each of these phenomena. These findings are consistent with previous experimental investigations and computer simulations, but pose significant challenges to current theories of cell sorting and tissue engulfment. [S0148-0731(00)01304-2].