Fast-Clearable Nanocarriers Conducting Chemo/Photothermal Combination Therapy to Inhibit Recurrence of Malignant Tumors
Fast-Clearable Nanocarriers Conducting Chemo/Photothermal Combination Therapy to Inhibit Recurrence of Malignant Tumors
复制标题
快速清除纳米载体进行化疗/光热联合疗法抑制恶性肿瘤复发
DOI：
10.1002/smll.201700963
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发表时间：
2017
期刊：
影响因子：
13.3
通讯作者：
Zhao Yanli
中科院分区：
文献类型：
--
作者：
Zhao Lingzhi;Yuan Wei;Huijun Phoebe Tham;Chen Hongzhong;Xing Pengyao;Xiang Huijing;Yao Xin;Qiu Xiaochen;Dai Yu;Zhu Liangliang;Li Fuyou;Zhao Yanli
在癌症治疗过程中，光热疗法（PTT）的不均匀加热常导致肿瘤复发。因此，将PTT与化疗（CHT）结合可能为提高治疗效率提供补充治疗。本研究开发了一种中空结构聚合物-二氧化硅纳米杂化物（HPSN）作为纳米载体，通过增强渗透和滞留效应，将抗癌药物紫杉醇和光热剂酞菁钯同时输送到肿瘤中。对侵袭性肿瘤移植小鼠进行了CHT/PTT联合治疗。单纯PTT治疗后复发的高度恶性肿瘤模型，可通过CHT/PTT联合治疗得到根治。此外，大多数脱靶HPSN纳米载体可在约10 d内通过肝胆途径排出体外。血清学结果表明，快速清除的HPSN可显著降低负载紫杉醇药物的副作用。本研究为肿瘤的联合治疗提供了一种新的途径。
Inhomogeneous heating by photothermal therapy (PTT) during cancer treatment often results in the recurrence of tumors. Thus, integrating PTT with chemotherapy (CHT) may provide a complementary treatment for enhanced therapeutic efficiency. Herein, this study develops a hollow structured polymer–silica nanohybrid (HPSN) as a nanocarrier to simultaneously deliver the anticancer drug paclitaxel and photothermal agent palladium phthalocyanine to tumors through enhanced permeation and the retention effect. A combinational CHT/PTT therapy on mice bearing aggressive tumor grafts is conducted. The highly malignant tumor model, which recurs after sole treatment of PTT, can be eradicated by the combined CHT/PTT treatment. In addition, most of the off‐targeted HPSN nanocarriers can be excreted through a hepatobiliary pathway in about 10 d. Serology results show that the fast‐clearable HPSN can significantly reduce the side effect of the loaded paclitaxel drug. The present work provides an alternative approach for combinational cancer treatment with high therapeutic efficiency.