ASSOCIATION FOR ACADEMIC SURGERY Race Disparities in Wilms Tumor Incidence and Biology
ASSOCIATION FOR ACADEMIC SURGERY Race Disparities in Wilms Tumor Incidence and Biology
复制标题
DOI：
10.1016/j.jss.2011.03.011
复制
发表时间：
2011-09-01
影响因子：
2.2
通讯作者：
Lovvorn, Harold N., III
中科院分区：
文献类型：
--
作者：
Axt, Jason;Murphy, Andrew J.;Lovvorn, Harold N., III
背景资料。威尔姆斯肿瘤(Wilms Tumor，WT)被认为在非洲黑人血统的儿童中发生的频率比白人更高。为了阐明WT中种族差异的生物学基础，我们首先验证了居住在田纳西州的黑人儿童WT的发病率增加，其次，建立了WT中种族特有的分子图谱。为了评估WT流行病学中的种族差异，田纳西州癌症登记处(TCR)查询了1999至2008年间登记的所有20岁以下的州内患者。对田纳西州采集的6例黑人和4例白人的WT标本进行了成像质谱仪(IMS)分析，探讨WT生物学上的种族差异。TCR数据显示，相对于所有其他儿童癌症(18.5%；P=0.01)，WT患者中黑人儿童的比例(29%)过高。WT在黑人最常见的癌症诊断中排名第五，在白人中排名第九。WT的诊断在黑人(n=28)中的发生率比白人(n=69；P=0.01)高79%，而且从比例上讲，更多的黑人倾向于出现远处疾病。尽管在黑人(92.9%)和白人(94.0%)中，WT的总体存活率没有统计学差异，但黑人男性的存活率最低(85%；P=0.21)。IMS分析鉴定了来自WT胚泡和基质的肽谱，根据种族独立地对样本进行分类，准确率超过80%。在田纳西州，黑人儿童似乎比白人更容易患上WT。可以确定特定种族的分子图谱，这可能有助于阐明Wilms肿瘤发生的途径，以及WT发病率和生物学上种族差异的生物学基础。(C)2011 Elsevier Inc.保留所有权利。
Background. Wilms tumor (WT) is thought to arise in children of Black African ancestry with greater frequency than in Whites. To clarify the biological basis for race disparities in WT, we first verified that Black children residing in Tennessee have an increased incidence of WT, and second, established molecular profiles in WT that are specific to race.Materials and Methods. To assess race disparities in WT epidemiology, the Tennessee Cancer Registry (TCR) was queried for all in-state patients less than 20 y of age and registered between 1999 and 2008. To explore race disparities in WT biology, six Black and four White WT specimens acquired in Tennessee were analyzed using imaging mass spectrometry (IMS).Results. TCR data show that Black children are over-represented among WT patients (29%) relative to all other childhood cancers (18.5%; P = 0.01). WT ranked the fifth most common cancer diagnosis among Blacks, but ninth among Whites. The diagnosis of WT occurred 79% more frequently among Blacks (n = 28) than Whites (n = 69; P = 0.01), and proportionally more Blacks tended to present with distant disease. Although overall survival from WT was not statistically different between Blacks (92.9%) and Whites (94.0%), Black males showed the lowest survival (85%; P = 0.21). IMS analysis identified peptide spectra from both WT blastema and stroma that independently classify specimens according to race with greater than 80% accuracy.Conclusions. In Tennessee, Black children appear more susceptible than Whites to develop WT. Race-specific molecular profiles can be determined that may help to clarify pathways of Wilms tumorigenesis and the biological basis for race disparities in WT incidence and biology. (C) 2011 Elsevier Inc. All rights reserved.