A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity
A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity
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DOI：
10.1053/ejso.2000.1056
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发表时间：
2001-02-01
期刊：
影响因子：
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通讯作者：
Picci, P
中科院分区：
文献类型：
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作者：
Bacci, G;Ferrari, S;Picci, P
目的：我们的经验，术前动脉内（i.a.）vs静脉内（i. v.）本文报告顺铂（CDP）在肢体骨肉瘤多药新辅助化疗中的应用。在第一个，术前，CDP i.a.与CDP静脉注射联合应用高剂量甲氨蝶呤（HDMTX）和阿霉素（ADM）的三种药物方案。第二组为HDMTX、ADM和IFO联合化疗。结果：化疗有效率（肿瘤坏死≥ 90%）明显高于对照组（P
Aim: Our experience of pre-operative intraarterial (i.a.) vs intravenous (i.v.) infusion of cisplatinum (CDP) in a multiagent neo-adjuvant chemotherapy for osteosarcoma of the extremity is reported,Methods: Two successive randomized studies were performed. In the first, pre-operatively, CDP i.a. vs CDP i.v. was applied in combination with high-dose methotrexate (HDMTX) and adriamycin (ADM) within a three-drug regimen. In the second, a combination of HDMTX, ADM and IFO, within a four-drug regimen was tested.Results: The rate of responses to chemotherapy (tumour necrosis greater than or equal to 90%) was significantly higher (P