Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
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DOI：
10.1038/clpt.2011.47
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发表时间：
2011-06
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
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幼儿患丙戊酸(VPA)肝毒性的风险增加。用丙戊酸(VPA；n=52)治疗的3.5-17.3岁癫痫患儿的尿液有机酸谱，作为线粒体功能的一种衡量指标。年龄匹配的卡马西平治疗组(n=50)和未治疗的健康儿童组(n=22)作为对照。在所有三组中都观察到了有机酸谱随年龄的变化。虽然主成分分析(PCA)得分图不能区分未治疗组和CBZ对照组，但VPA组和对照组/CBZ组之间有明显的界限。在VPA诱导的反映支链氨基酸代谢和氧化应激的内源途径的改变中观察到个体间的差异。这些数据表明，更详细的代谢组学分析可能为严重中毒风险最高的儿童提供对生物机制和预测性生物标志物的新见解。
Young children are at increased risk for valproic acid (VPA) hepatotoxicity. Urinary organic acid profiles, as a measure of mitochondrial function, were obtained in children 3.5 to 17.3 years old treated for seizure disorders with valproic acid (VPA; n=52). Age-matched patients treated with carbamazepine (CBZ; n=50) and untreated healthy children (n=22) served as controls. Age-related changes in organic acid profiles were observed in all three groups. Although untreated and CBZ control subjects were not distinguished by the principal component analysis (PCA) scores plot, a distinct boundary was apparent between the VPA and control/CBZ groups. Inter-individual variability in VPA-induced alterations in endogenous pathways reflecting branched chain amino acid metabolism and oxidative stress was observed. The data suggest that more detailed metabolomic analysis may provide novel insights into biological mechanisms and predictive biomarkers for children at highest risk for serious toxicity.
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影响因子：
6.8
作者：
Boulat, O;Gradwohl, M;Bachmann, C
通讯作者：
Bachmann, C
影响因子：
56.9
作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.6
作者：
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通讯作者：
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