Bactericidal Activity of Quinupristin-Dalfopristin against Staphylococcus aureus: Clindamycin Susceptibility as a Surrogate Indicator
Bactericidal Activity of Quinupristin-Dalfopristin against Staphylococcus aureus: Clindamycin Susceptibility as a Surrogate Indicator
复制标题
奎奴普汀-达福普汀对金黄色葡萄球菌的杀菌活性：克林霉素敏感性作为替代指标
DOI：
10.1128/aac.44.10.2880-2882.2000
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发表时间：
2000
影响因子：
4.9
通讯作者：
Steven D. Brown
中科院分区：
文献类型：
--
作者：
P. Fuchs;A. Barry;Steven D. Brown
在516株检测的金黄色葡萄球菌中，97.1%对奎奴普汀-达福普汀敏感，其对39株检测菌株中的22株（56%）具有杀菌作用，与万古霉素相当。所有17个克林霉素和大环内酯类耐药菌株被抑制，但不杀死奎奴普汀-达福普汀，而所有22个克林霉素敏感菌株（5个大环内酯类耐药）被杀死。
ABSTRACT Of 516 Staphylococcus aureus strains tested, 97.1% were susceptible to quinupristin-dalfopristin, which was bactericidal for 22 (56%) of the 39 strains tested, comparable to vancomycin. All 17 clindamycin and macrolide-resistant strains were inhibited but not killed by quinupristin-dalfopristin, whereas all 22 clindamycin-susceptible strains (5 were macrolide resistant) were killed.