Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation.
Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation.
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增强子的非编码转录本：对增强子活性和基因表达调控的新见解
DOI：
10.1016/j.gpb.2017.02.003
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Chen H;Du G;Song X;Li L
长链非编码RNA（longnon-codingRNA，lncRNA）由于其数量巨大、功能惊人，在生物学过程中发挥着重要作用，在近十年来引起了人们的广泛关注。一些lncRNA发挥增强子的功能，即，作为顺式调节分子激活基因转录。此外，最近的研究表明，许多增强子元件可以被转录并产生RNA分子，这些RNA分子被称为增强子RNA（eRNA）。eRNA不仅仅是增强子转录的副产物。事实上，它们中的许多通过不同的机制直接发挥或调节基因激活中的增强子活性。本文综述了增强子的活性、增强子自身的转录、eRNA的特性及其在调控增强子活性和基因表达中的作用。
Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.
DOI：
10.1007/978-1-60327-461-6_7
发表时间：
2009
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Miele, Adriana;Dekker, Job
通讯作者：
Dekker, Job