Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity.
Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity.
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人8-氧气DNA糖基化酶在肺上皮细胞中增加对高氧细胞毒性的耐药性，并参与改变MAPK活性。
DOI：
10.1038/sj.cdd.4401736
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发表时间：
2006-03
影响因子：
12.4
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Kannan S;Pang H;Foster DC;Rao Z;Wu M
It is unknown whether base excision DNA repair (BER) proteins interact with mitogen-activated protein kinases (MAPK) under oxidation. Here, we explored roles of BER proteins in signaling transduction involving MAPK during hyperoxia. We demonstrated that ERK1/2 phosphorylation in A549 cells was increased in 95% O2. p38 activity in A549 cells was also increased by exposure to 95% O2. To evaluate regulatory roles of MAPK, we have transduced A549 cells and primary alveolar epithelial type II cells (AECII) to overexpress 8-oxoguanine DNA glycosylase (hOgg1). Overexpression of hOgg1 reduced hyperoxic toxicity in A549 and AECII cells. Furthermore, protection by BER against hyperoxia appeared to involve an upregulation of ERK1/2 and downregulation of p38. These observations demonstrate, for the first time, that reduction of hyperoxic toxicity by BER proteins may be involved with MAPK activity, thereby impacting cell survival. Furthermore, our studies suggest that modulation of MAPK may be used in combination with BER proteins to counteract hyperoxic toxicity.
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影响因子：
64.5
作者：
FISHER, RP;MORGAN, DO
通讯作者：
MORGAN, DO
DOI：
10.1152/ajplung.1998.274.5.l714
发表时间：
1998-05-01
影响因子：
4.9
作者：
Buckley, S;Barsky, L;Warburton, D
通讯作者：
Warburton, D
DOI：
10.1111/j.1749-6632.1999.tb07931.x
发表时间：
1999-01-01
期刊：
MECHANISMS OF CELL DEATH
影响因子：
--
作者：
Mantell, LL;Horowitz, S;Kazzaz, JA
通讯作者：
Kazzaz, JA
DOI：
10.1165/ajrcmb.22.5.f180
发表时间：
2000-05-01
影响因子：
6.4
作者：
Barazzone, C;White, CW
通讯作者：
White, CW
DOI：
10.1073/pnas.38.4.289
发表时间：
1952-01-01
影响因子：
11.1
作者：
CONGER, AD;FAIRCHILD, LM
通讯作者：
FAIRCHILD, LM