Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing
Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing
复制标题
受皮肤启发的基于明胶的柔性生物电子水凝胶，用于促进伤口愈合和运动传感
DOI：
10.1016/j.biomaterials.2021.121026
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发表时间：
2021
期刊：
影响因子：
14
通讯作者：
Guo Junling
中科院分区：
文献类型：
--
作者：
Zheng Manhui;Wang Xuechuan;Yue Ouyang;Hou Mengdi;Zhang Huijie;Beyer Sebastian;Blocki Anna Maria;Wang Qin;Gong Guidong;Liu Xinhua;Guo Junling
下一代组织工程皮肤支架有望通过电刺激提供感觉恢复，除了有效地重建和修复皮肤。通过对损伤运动活动的实时监测，可以从根本上提高治疗效果，提供详细的数据来指导临床实践。本文中，机械柔性、电活性和可自愈的水凝胶（MESGel）被设计用于电刺激加速伤口愈合和运动感测的组合功能。MESGel具有出色的生物相容性和多功能治疗特性，包括柔韧性、自愈特性、生物降解性和生物电活性。此外，MESGel显示了其作为一种新型的柔性电子皮肤传感器记录损伤运动活动的潜力。全面的体外体内实验证明，MESGel可以促进有效的电刺激，积极促进中国仓鼠肺上皮细胞的增殖，因此可以在皮肤伤口愈合期间加速有利的上皮生物学，证明了全层皮肤缺损模型的有效治疗策略，并导致新型柔性生物电子学。
Next generation tissue-engineered skin scaffolds promise to provide sensory restoration through electrical stimulation in addition to effectively rebuilding and repairing skin. The integration of real-time monitoring of the injury motion activities can fundamentally improve the therapeutic efficacy by providing detailed data to guide the clinical practice. Herein, a mechanically-flexible, electroactive, and self-healable hydrogels (MESGel) was engineered for the combinational function of electrically-stimulated accelerated wound healing and motion sensing. MESGel shows outstanding biocompatibility and multifunctional therapeutic properties including flexibility, self-healing characteristics, biodegradability, and bioelectroactivity. Moreover, MESGel shows its potential of being a novel flexible electronic skin sensor to record the injury motion activities. Comprehensivein vitroandin vivoexperiments prove that MESGel can facilitate effective electrical stimulation, actively promoting proliferation in Chinese hamster lung epithelial cells and therefore can accelerate favorable epithelial biology during skin wound healing, demonstrating an effective therapeutic strategy for a full-thickness skin defect model and leading to new-type flexible bioelectronics.