Ups and downs of lysosomal pH: conflicting roles of LAMP proteins?
Ups and downs of lysosomal pH: conflicting roles of LAMP proteins?
复制标题
溶酶体 pH 值的起伏：LAMP 蛋白的相互冲突的作用？
DOI：
10.1080/15548627.2023.2274253
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发表时间：
2023
期刊：
影响因子：
13.3
通讯作者：
Jenny, Andreas
中科院分区：
文献类型：
--
作者：
Handy, Jonathan;Macintosh, Gustavo C.;Jenny, Andreas
溶酶体的酸性pH值对于真核细胞中的催化剂是至关重要的，并且在神经退行性疾病（包括阿尔茨海默病和帕金森病）中改变。最近使用果蝇和哺乳动物细胞培养系统的报道已经确定了溶酶体相关膜蛋白（LAMP）在调节内溶酶体系统中的新的和乍一看是矛盾的作用。缩写：AD：阿尔茨海默病; LAMP：溶酶体相关膜蛋白; LTR：LysoTracker; PD：帕金森病; TMEM 175：跨膜蛋白175; V-ATP酶：空泡型H+转运ATP酶
The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer and Parkinson. Recent reports using Drosophila and mammalian cell culture systems have identified novel and, at first sight, conflicting roles for the lysosomal associated membrane proteins (LAMPs) in the regulation of the endolysosomal system.Abbreviation:AD: Alzheimer disease; LAMP: lysosomal associated membrane protein; LTR: LysoTracker; PD: Parkinson disease; TMEM175: transmembrane protein 175; V-ATPase: vacuolar-type H+-translocating ATPase