Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation
Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation
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通过靶向和局部光激活提高癌症治疗效率
DOI：
10.1021/acsami.7b05463
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发表时间：
2017
影响因子：
9.5
通讯作者：
Zhou Xin
中科院分区：
文献类型：
--
作者：
Yang Yuqi;Chen Shizhen;Liu Lianhua;Li Sha;Zen Qingbin;Zhao Xiuchao;Li Haidong;Zhang Zhiying;Bouchard Louis S;Liu Maili;Zhou Xin
目前，癌症治疗的潜力受到与肿瘤特异性、药物获取和有限疗效相关的各种问题的影响。我们报告了一种利用光响应纳米结构提高癌症治疗有效性的新方法。通过加热和自由基的产生来增强药物的吸收，从而增加药效。通过纳米结构的化学靶向和光传递到肿瘤的定位，增加了治疗特异性。当到达肿瘤时，磁共振成像增强，近红外荧光在药物释放时被激活，使得在组织和细胞水平上可视化局部治疗成为可能。这种双模成像纳米结构使实体瘤的协同治疗和观察评估具有显著提高的疗效，为癌症治疗和评估提供了一种有希望的新方法。
Currently, the potential of cancer therapy is compromised by a variety of problems related to tumor specificity, drug access, and limited efficacy. We report a novel approach to improve the effectiveness of cancer treatment utilizing a light-responsive nanoconstruct. Effectiveness is increased by enhancing drug absorption through heating and the production of free radicals. Treatment specificity is increased through chemical targeting of the nanoconstruct and localization of light delivery to the tumor. When reaching the tumor, magnetic resonance imaging is enhanced and near-infrared fluorescence is activated upon drug release, making it possible to visualize the localized treatment at both the tissue and cellular levels. This dual-modality imaging nanoconstruct enables the synergistic treatment and observable evaluation of solid tumors with dramatically improved efficacy, giving rise to a promising new approach for cancer therapy and evaluation.