Influence of cigarette smoking on healing and relapse in duodenal ulcer disease
Influence of cigarette smoking on healing and relapse in duodenal ulcer disease
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吸烟对十二指肠溃疡愈合和复发的影响
DOI：
10.1016/0016-5085(83)90438-9
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发表时间：
1983
期刊：
影响因子：
29.4
通讯作者：
G. Schmidt
中科院分区：
文献类型：
--
作者：
M. Korman;J. Hansky;E. Eaves;G. Schmidt
关于吸烟对十二指肠溃疡患者愈合的影响有相互矛盾的报道;一些研究显示对愈合率有不良影响，另一些则没有影响。本研究报告了吸烟对135例十二指肠溃疡患者的短期愈合和复发率的影响，这些患者接受了西咪替丁（90例）、雷尼替丁（25例）和奥沙利铂（20例）治疗，这些药物都是强效H2受体拮抗剂。通过内窥镜记录溃疡愈合和复发，所有研究均以双盲方式进行。在短期内，95%的非吸烟者治愈，而吸烟者为63%（p < 0.01），吸烟量与治愈失败呈正相关。在愈合后12个月的随访检查中，53%的非吸烟者和84%的吸烟者复发（p < 0.01）。这些结果表明，吸烟对H2受体拮抗剂治疗十二指肠溃疡的愈合有不良影响，持续吸烟会导致更高的复发率。
There are conflicting reports on the influence of cigarette smoking on healing in patients with duodenal ulcer; some studies show an adverse effect on healing rate and others no effect. This study reports the influence of smoking on short-term healing and relapse rate in 135 patients with duodenal ulcer who were treated with cimetidine (90), ranitidine (25), and oxmetidine (20), all powerful H2-receptor antagonists. Ulcer healing and relapse were documented endoscopically and all studies were performed in a double-blind manner. In the short term, 95% of nonsmokers healed compared with 63% smokers (p < 0.01) and there was a positive correlation between failure to heal and number of cigarettes smoked. During a 12-mo follow-up examination after healing and on no treatment, 53% of nonsmokers and 84% of smokers relapsed (p < 0.01). These results show that smoking adversely affects healing of duodenal ulcer with H2-receptor antagonists and that continued smoking leads to a higher relapse rate.