Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography
Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography
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DOI：
10.1364/oe.15.013574
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发表时间：
2007-10-17
期刊：
影响因子：
3.8
通讯作者：
Andersson-Engels, Stefan
中科院分区：
文献类型：
--
作者：
Axelsson, Johan;Svensson, Jenny;Andersson-Engels, Stefan
荧光分子层析成像在数学上是病态的，导致重建问题的解不是唯一的。为了减少重建中欠定方程组中可能解的数目，我们提出了一种方法来检索空间变化的正则化映射，该映射勾勒出可行的包含位置。通过只包含来自一个震源位置的几个多光谱记录，这种方法可以变得非常简单。通过组织模体实验检索的结果表明，具有空间变化的先验的初始重建减少了伪影，并且与使用没有先验的重建相比，显示出稍微更准确的重建结果。(C)2007年美国光学学会。
Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors. (C) 2007 Optical Society of America.