Fetal alcohol spectrum disorders: Extending the range of structural defects.
Fetal alcohol spectrum disorders: Extending the range of structural defects.
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DOI：
10.1002/ajmg.a.33675
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发表时间：
2010-11
影响因子：
2
通讯作者：
Chambers, Christina D.
中科院分区：
文献类型：
--
作者：
Jones, Kenneth Lyons;Hoyme, H. Eugene;Robinson, Luther K.;del Campo, Miguel;Manning, Melanie A.;Prewitt, Lela M.;Chambers, Christina D.
虽然胎儿酒精综合征（FAS）的结构表型已经确定，但产前暴露于酒精可能会产生更广泛的缺陷，即胎儿酒精谱系障碍（FASD）。记录与FASD相关的所有缺陷对于确定这种疾病的真实发病率至关重要。我们检查了831名来自胎儿酒精谱系障碍合作计划的儿童，使用结构化协议诊断FAS，使用主要的面部和生长特征，并评估产前酒精暴露儿童更常发生的其他结构缺陷。受试者被分类为FAS、延迟（FAS的一些特征性特征）或无FAS，根据观察到的其他特征的患病率和数量比较各组，按诊断类别、性别、人种和年龄分层。大多数其他特征的患病率在有FAS的受试者中最高，在无FAS的受试者中最低。在FAS和≥12岁的递延受试者中观察到的其他特征频率高于12岁以下受试者。FAS和递延白人有更大的频率比海角有色的额外功能。产前酒精暴露可能会产生广泛的结构缺陷，超出FAS与酒精对胎儿发育的影响，最终预防FASD的先决条件。
Although the structural phenotype of Fetal Alcohol Syndrome (FAS) is established, prenatal exposure to alcohol may produce a broader spectrum of defects, Fetal Alcohol Spectrum Disorder (FASD). Documenting the full spectrum of defects associated with FASD is critical to determining the true incidence of this disorder. We examined 831 children from the Collaborative Initiative on Fetal Alcohol Spectrum Disorders using a structured protocol for diagnosis of FAS using the cardinal facial and growth features, and assessment of additional structural defects thought to occur more often in children with prenatal alcohol exposure. Subjects were classified as FAS, Deferred (some characteristic features of FAS) or No FAS, Groups were compared on prevalence of additional features and number of additional features observed, stratified by diagnostic category, sex, race and age. Prevalence of most additional features was greatest among subjects with FAS and least among No FAS. A higher frequency of additional features was observed among FAS and Deferred subjects ≥12 years of age than among those under 12. FAS and Deferred Whites had greater frequency of additional features than Cape Colored. Prenatal alcohol exposure may produce a broad spectrum of structural defects that goes beyond FAS with implications regarding the impact of alcohol on the developing fetus, a prerequisite for ultimate prevention of FASD.
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影响因子：
14.6
作者：
Chudley, AE;Conry, J;LeBlanc, N
通讯作者：
LeBlanc, N
影响因子：
2
作者：
Autti-Rämö, I;Fagerlund, Å;Hoyme, HE
通讯作者：
Hoyme, HE
影响因子：
8
作者：
Hoyme, HE;May, PA;Robinson, LK
通讯作者：
Robinson, LK
影响因子：
0.3
作者：
Burd, Larry;Deal, Eric;Klug, Marilyn G
通讯作者：
Klug, Marilyn G
影响因子：
2.8
作者：
Astley, SJ;Clarren, SK
通讯作者：
Clarren, SK