The role of ARF and Rab GTPases in membrane transport
The role of ARF and Rab GTPases in membrane transport
复制标题
DOI：
10.1016/s0955-0674(99)80067-2
复制
发表时间：
1999-08-01
影响因子：
7.5
通讯作者：
Goud, B
中科院分区：
文献类型：
--
作者：
Chavrier, P;Goud, B
真核细胞内转运和膜转运的两个关键事件，即转运囊泡的形成和其向靶膜的特异性转运，分别由ADP-核糖化因子(ARF)和Rab家族的小GTP酶控制。在过去的18个月里，已经发现了调节ARF和Rab GDP/GTP循环的蛋白质，以及它们的效应者的特征，从而揭示了ARF和Rab功能的分子机制。
Two key events of intracellular transport and membrane trafficking in eukaryotic cells, the formation of transport vesicles and their specific delivery to target membranes, are controlled by small GTPases of the ADP-ribosylation factor (ARF) and Rab families, respectively. The past 18 months have seen the identification of proteins that regulate ARF and Rab GDP/GTP cycle, as well as the characterization of their effecters, shedding light on the molecular mechanisms of ARF and Rab function.