The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function.
The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function.
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DOI：
10.3390/membranes1040354
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发表时间：
2011-12-09
期刊：
影响因子：
4.2
通讯作者：
Nakamura N
中科院分区：
文献类型：
--
作者：
Nakamura N
在真核细胞中存在大量的RING finger（RNF）蛋白，其中大多数被认为是E3泛素连接酶。在人类中，49种RNF蛋白被预测含有跨膜结构域，其中几种特异性地定位于分泌和内吞途径中的膜隔室，以及线粒体和过氧化物酶体。它们被认为是细胞膜和膜性细胞器的功能和动态结构的组织和完整性的分子调节剂。新出现的证据表明，跨膜RNF蛋白控制着参与细胞和生理过程许多方面的蛋白质的稳定性、运输和活性。本文综述了哺乳动物跨膜RNF蛋白的研究进展，重点介绍了其功能和意义。
A large number of RING finger (RNF) proteins are present in eukaryotic cells and the majority of them are believed to act as E3 ubiquitin ligases. In humans, 49 RNF proteins are predicted to contain transmembrane domains, several of which are specifically localized to membrane compartments in the secretory and endocytic pathways, as well as to mitochondria and peroxisomes. They are thought to be molecular regulators of the organization and integrity of the functions and dynamic architecture of cellular membrane and membranous organelles. Emerging evidence has suggested that transmembrane RNF proteins control the stability, trafficking and activity of proteins that are involved in many aspects of cellular and physiological processes. This review summarizes the current knowledge of mammalian transmembrane RNF proteins, focusing on their roles and significance.