EXPRESSION OF FATTY-ACID-BINDING PROTEIN IN THE LIVER DURING PREGNANCY AND LACTATION IN THE RAT
EXPRESSION OF FATTY-ACID-BINDING PROTEIN IN THE LIVER DURING PREGNANCY AND LACTATION IN THE RAT
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DOI：
10.1016/0005-2760(95)00114-r
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发表时间：
1995-09-14
期刊：
影响因子：
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通讯作者：
CARLIER, H
中科院分区：
文献类型：
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作者：
BESNARD, P;FOUCAUD, L;CARLIER, H
研究了妊娠和哺乳期大鼠肝脏脂肪酸结合蛋白（L-FABP）的表达。免疫酶法（ELISA）的细胞质中发现的L-FABP浓度始终高于母鼠在怀孕期间和哺乳期比年龄匹配的处女女性。在妊娠的最后几天，母鼠肝脏中L-FABP mRNA水平下降，在哺乳期的第7天和第14天，这一水平仍然很低。由于L-FABP基因的转录速率在母体肝脏中不变，这些数据表明在大鼠妊娠和哺乳期间L-FABP的转录后调节。在怀孕和哺乳期间发生的营养适应不参与这一调节，因为长期母亲的食物限制未能纠正这些修改。这种调节的机制目前尚不清楚，但可能包括神经介导的作用。
Expression of the liver fatty acid binding protein (L-FABP) has been studied in the liver of pregnant and lactating rats. The L-FABP concentration found in the cytosol by immuno-enzymatic assay (ELISA) was consistently higher in the dams during the pregnancy and the lactation than in the age-matched virgin females. Paradoxically, a decrease in the L-FABP mRNA level occurred in the maternal liver during the last days of the gestation, This level remained low on days 7 and 14 of the lactation. Since the transcription rate of the L-FABP gene was unchanged in the maternal liver, these data suggest a post-transcriptional regulation of the L-FABP during pregnancy and lactation in the rat. The nutritional adaptations occurring during pregnancy and lactation are not involved in this regulation since a chronic maternal food-restriction failed to correct these modifications. The mechanism of this regulation is presently unknown, but possibilities include hormonally mediated effects.