Involvement of the gapA- and epd(gapB)-Encoded Dehydrogenases in Pyridoxal 5′-Phosphate Coenzyme Biosynthesis in Escherichia coli K-12
Involvement of the gapA- and epd(gapB)-Encoded Dehydrogenases in Pyridoxal 5′-Phosphate Coenzyme Biosynthesis in Escherichia coli K-12
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DOI：
10.1128/jb.180.16.4294-4299.1998
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发表时间：
1998-08
影响因子：
3.2
通讯作者：
Yong Yang;Genshi Zhao;T. Man;M. Winkler
中科院分区：
文献类型：
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作者：
Yong Yang;Genshi Zhao;T. Man;M. Winkler
ABSTRACT We show that epd (gapB) mutants lacking an erythrose 4-phosphate (E4P) dehydrogenase are impaired for growth on some media and contain less pyridoxal 5′-phosphate (PLP) and pyridoxamine 5′-phosphate (PMP) than their epd+parent. In contrast to a previous report, we found that gapA epd double mutants lacking the glyceraldehyde 3-phosphate and E4P dehydrogenases are auxotrophic for pyridoxine. These results implicate the GapA and Epd dehydrogenases in de novo PLP and PMP coenzyme biosynthesis.
