The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar I disorder
The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar I disorder
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DOI：
10.1002/ajmg.b.32055
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发表时间：
2012-07-01
影响因子：
2.8
通讯作者：
Lu, Ru-Band
中科院分区：
文献类型：
--
作者：
Huang, Chih-Chun;Chang, Yun-Hsuan;Lu, Ru-Band
双相情感障碍I （BP-I）和双相情感障碍II （BP-II）是双相情感障碍最常见的两种亚型。然而，大多数研究并没有将双相情感障碍分为BP-I和BP-II组，因此区分这两种亚型的潜在病因尚不清楚。这两种亚型之间的遗传关联对于提高我们的认识至关重要。多巴胺D2受体/锚蛋白重复和激酶结构域1 （DRD2/ANKK1）是多巴胺能通路之一，脑源性神经营养因子（BDNF）基因被报道为双相情感障碍病因的候选基因。因此，我们研究了BDNF和DRD2/ANKK1基因对BP-I和BP-II分化的贡献及其相互作用。共招募了792名参与者：208名患有BP-I， 329名患有BP-II， 255名健康对照。采用聚合酶链反应加限制性片段长度多态性分析确定BDNF和DRD2/ANKK1 Taq1A多态性的基因型。BDNF Val66Met多态性的Val/Val基因型对BP-II患者有显著的主要影响。BDNF Val66Met多态性的Val/Val基因型与DRD2/ANKK1 Taq1A多态性的A1/A2基因型的交互作用仅在BP-II患者中发现。我们提供的初步证据表明，BDNF Val66Me和DRD2/ANKK1 Taq1A多态性仅在BP-II疾病中相互作用，并且BP-I和BP-II在遗传上是不同的。(C) 2012 Wiley期刊公司
Bipolar I (BP-I) and bipolar II (BP-II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP-I and BP-II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain-derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP-I and BP-II. Seven hundred ninety-two participants were recruited: 208 with BP-I, 329 with BP-II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP-II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP-II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP-II disorder and that BP-I and BP-II are genetically distinct. (C) 2012 Wiley Periodicals, Inc.