Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.
Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.
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DOI：
10.1042/bj20110112
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发表时间：
2011-07-01
期刊：
影响因子：
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通讯作者：
Stack MS
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文献类型：
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作者：
Barbolina MV;Burkhalter RJ;Stack MS
Wnt信号通路已被证明在正常发育和肿瘤发生中发挥关键作用。许多人类癌症的进展与Wnt通路成分的明确突变相关，这些突变导致β-连环蛋白介导的基因转录失调。尽管Wnt通路突变在上皮性卵巢癌中很少见（子宫内膜样组织型除外），但越来越多的证据支持Wnt信号在没有基因突变的情况下在卵巢肿瘤发生中的作用。本综述总结了支持卵巢肿瘤中激活Wnt信号的证据，并讨论了卵巢肿瘤微环境中Wnt通路激活的替代机制。
Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with defined mutations in Wnt pathway components that result in dysregulated β-catenin-mediated gene transcription. Although Wnt pathway mutations are rare in epithelial ovarian cancer (with the exception of the endometrioid histotype), accumulating evidence supports a role for Wnt signalling in ovarian tumorigenesis in the absence of genetic mutations. The present review summarizes evidence in support of activated Wnt signalling in ovarian tumours and discusses alternative mechanisms for Wnt pathway activation in the ovarian tumour microenvironment.