Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus
Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus
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DOI：
10.1016/j.vaccine.2009.05.044
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发表时间：
2009-07-16
期刊：
影响因子：
5.5
通讯作者：
MacLachlan, N. James
中科院分区：
文献类型：
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作者：
Guthrie, Alan J.;Quan, Melvyn;MacLachlan, N. James
我们描述了一种重组金丝雀痘病毒载体（ALVAC（R））疫苗的开发和初步特性，用于保护性免疫马类动物，以防止非洲马疫病毒（AHSV）感染。用两种浓度的共表达编码AHSV血清4型（AHSV-4）外衣壳蛋白（VP 2和VP 5）的合成基因的重组金丝雀痘病毒载体（ALVAC-AHSV）免疫的马（n = 8）产生了不同的滴度（
We describe the development and preliminary characterization of a recombinant canarypox virus vectored (ALVAC (R))vaccine for protective immunization of equids against African horsesickness virus (AHSV) infection. Horses (n = 8) immunized with either of two concentrations of recombinant canarypox virus vector (ALVAC-AHSV) co-expressing synthetic genes encoding the outer capsid proteins (VP2 and VP5) of AHSV serotype 4 (AHSV-4) developed variable titres (