Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line
Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line
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DOI：
10.1002/(sici)1521-186x(1997)18:8
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发表时间：
1997-01-01
影响因子：
1.9
通讯作者：
Liburdy, RP
中科院分区：
文献类型：
--
作者：
Harland, JD;Liburdy, RP
我们以前曾报道过，环境水平的磁场（1.2 μ T [12毫高斯]，60 Hz）在体外阻断褪黑素（10（-9）M）对MCF-7人乳腺癌细胞的生长抑制。我们现在报告，同样的1.2 μ T，60 HZ磁场显著阻断药理水平的他莫昔芬（10（-7）M）的生长抑制作用。在生物物理学研究中，我们利用了法拉第电流感应定律，并测试了1.2 μ T磁场或相关的感应电场是否对褪黑激素和他莫昔芬产生场效应。我们观察到，磁场成分与场阻断褪黑素和他莫昔芬功能的影响。据我们所知，他莫昔芬的研究代表了第一个实验证据的环境水平的磁场修饰药物与人类乳腺癌细胞的相互作用。总之，这些发现为环境水平的磁场可以改变药物或激素对细胞增殖调节的作用的理论提供了支持。褪黑激素和他莫昔芬可能通过不同的生物途径下调细胞生长，并需要进一步的研究，以确定一个特定的生物网站的相互作用的1.2亩T的磁场。(C)1997 Wiley-Liss，Inc.匕首。
We have previously reported that environmental-level magnetic fields (1.2 mu T [12 milligauss], 60 Hz) block the growth inhibition of the hormone melatonin (10(-9) M) on MCF-7 human breast cancer cells in vitro. We now report that the same 1.2 mu T, 60 HZ magnetic fields significantly block the growth inhibitory action of pharmacological levels of tamoxifen (10(-7) M). In biophysical studies we have taken advantage of Faraday's Law of Current Induction and tested whether the 1.2 mu T magnetic field or the associated induced electric field is responsible for this field effect on melatonin and tamoxifen. We observe that the magnetic field component is associated with the field blocking effect on melatonin and tamoxifen function. To our knowledge the tamoxifen studies represent the first experimental evidence for an environmental-level magnetic field modification of drug interaction with human breast cancer cells. Together, these findings provide support to the theory that environmental-level magnetic fields can act to modify the action of a drug or hormone on regulation of cell proliferation. Melatonin and tamoxifen may act through different biological pathways to down-regulate cell growth, and further studies are required to identify a specific biological site of interaction for the 1.2 mu T magnetic field. (C) 1997 Wiley-Liss, Inc.dagger.