The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia
The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia
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DOI：
10.1158/0008-5472.can-04-0044
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发表时间：
2004-05-15
期刊：
影响因子：
11.2
通讯作者：
Resar, LMS
中科院分区：
文献类型：
--
作者：
Xu, Y;Sumter, TF;Resar, LMS
HMG-I/Y在人类癌症中过度表达，尽管该基因在转化中的直接作用尚未确定。我们产生了HMG-I靶向淋巴样细胞的转基因小鼠。所有7只信息丰富的创始人HMG-I小鼠在平均年龄4.8个月时发展为侵袭性淋巴瘤。肿瘤表达t细胞标记物，可移植。我们也证实了HMG-I mRNA和蛋白在人类急性淋巴细胞白血病样本中升高。我们的研究结果表明，HMG-I作为一种致癌基因发挥作用，并提示它有助于白血病和其他HMG-I表达增加的癌症的发病机制。
HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.