Clinical Study on Selective Enhancement of Drug Delivery by Angiotensin II in Cancer Chemotherapy
Clinical Study on Selective Enhancement of Drug Delivery by Angiotensin II in Cancer Chemotherapy
复制标题
血管紧张素II在癌症化疗中选择性增强药物递送的临床研究
DOI：
10.1007/978-94-009-8925-2_75
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Maroh Suzuki
中科院分区：
文献类型：
--
作者：
Haruo Sato;Kazunori Sato;Y. Sato;Y. Mimata;M. Asamura;R. Kanamuru;A. Wakui;Maroh Suzuki
In a series of experimental studies marked increase of blood flow was noted in tumor tissue with elevated blood pressure produced by angiotensin II, while no increase was detected in normal tissues (Suzuki et al., 1977a,1978,1979a,b). Thus, the functional difference between tumor and normal vessels could be applied selectively in cancer chemotherapy to enhance the delivery of drugs to tumor tissue (Suzuki et al., 1977b, 1980). This paper deals with the procedures and results obtained in clinical cancer chemotherapy studies (Sato et al., 1979b, c) which have used the concept based on the above experimental observations.
