Reaction of Glyconitriles with Organometallic Reagents: Access to Acyl β-C-Glycosides
Reaction of Glyconitriles with Organometallic Reagents: Access to Acyl β-C-Glycosides
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DOI：
10.1021/acs.joc.5b02853
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发表时间：
2016-03-18
影响因子：
3.6
通讯作者：
Guillarme, Stephane
中科院分区：
文献类型：
--
作者：
Guisot, Nicolas E. S.;Obame, Idriss Ella;Guillarme, Stephane
A new strategy for the synthesis of acyl beta-C-glycosides is described. The reactivity of glyconitriles toward organometallic reagents such as organomagnesium or organolithium derivatives was studied, affording acyl beta-C-glycosides in moderate to good yields. In this study, glycal formation was efficiently prevented by deprotonating the hydroxyl group in position 2 of the glyconitriles during the process.
