Gene encoding T-cell-activating protein TAP maps to the Ly-6 locus.
Gene encoding T-cell-activating protein TAP maps to the Ly-6 locus.
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编码 T 细胞激活蛋白 TAP 的基因定位到 Ly-6 基因座。
DOI：
10.1073/pnas.83.9.2954
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发表时间：
1986
影响因子：
11.1
通讯作者：
Rock,KL
中科院分区：
文献类型：
--
作者：
Reiser,H;Yeh,ET;Gramm,CF;Benacerraf,B;Rock,KL
最近，我们描述了两个小鼠T细胞膜蛋白，TAP（T细胞活化蛋白）和TAPa（TAP相关蛋白）。先前的实验表明TAP参与生理性T细胞活化。本报告的主题是这些分子的遗传分析。TAP和TAPa定位于Ly-6基因座。检查这些分子与该位点中编码的其他抗原的关系。基于组织分布、分子结构和功能特性，TAP不同于任何先前描述的Ly-6抗原，而TAPa可能与34-11-3抗原相同。TAP和TAPa在迄今为止检查的所有细胞类型上共表达。此外，比较研究表明，该基因座编码的分子表达存在复杂的发育调节模式。
Recently we described two murine T-cell membrane proteins, TAP (T-cell-activating protein) and TAPa (TAP-associated protein). Previous experiments suggested that TAP is involved in physiologic T-cell activation. The subject of this report is a genetic analysis of these molecules. TAP and TAPa map to the Ly-6 locus. The relationship of these molecules to other antigens encoded in this locus is examined. Based on tissue distribution, molecular structure, and functional properties, TAP is distinct from any previously described Ly-6 antigen, whereas TAPa is probably identical to the 34-11-3 antigen. TAP and TAPa are coexpressed on all cell types examined so far. Moreover, comparative studies demonstrate a complex developmentally regulated pattern in the expression of molecules encoded in this locus.