Increased mortality in African Americans with idiopathic pulmonary arterial hypertension
Increased mortality in African Americans with idiopathic pulmonary arterial hypertension
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DOI：
10.1016/s0027-9684(15)31177-9
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Doyle, Ramona L.
中科院分区：
文献类型：
--
作者：
Davis, Kala K.;Lilienfeld, David E.;Doyle, Ramona L.
背景：特发性肺动脉高压（IPAH）是一种进行性疾病，通常在未经治疗的情况下导致右心室衰竭和死亡。目的：评估1994-1998年美国特发性肺动脉高压的种族和性别死亡率趋势。方法：回顾美国国家卫生统计中心1994-1998年的死亡数据，其中潜在原因是原发性肺动脉高压（ICD9代码416.0），现在称为IPAH。死者的年龄、性别、种族和居住地从美国疾病控制中心Wonder系统（http://wonder.cdc .gov）中提取。然后计算出按年龄调整地区、种族和性别的年平均比率。结果：与其他种族和性别群体相比，非裔美国妇女在所有年龄组中表现出最高的IPAH死亡率。没有注意到死亡率的地域差异。在所有种族和性别群体中，随着年龄的增长，死亡率都有所增加，其中老年人的IPAH死亡率最高。讨论：非裔美国人患IPAH的死亡率明显高于白种人，尤其是非裔美国妇女。
Background: Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disorder that usually culminates in right ventricular failure and death without treatment.Objective: To assess mortality trends by race and gender for idiopathic pulmonary arterial hypertension in the United States from 1994-1998.Methods: The U.S. National Center for Health Statistics data for the years 1994-1998 was reviewed for deaths in which the underlying cause was primary pulmonary hypertension (ICD9 code 416.0), now known as IPAH. The age, gender, race and state of residence of the deceased were abstracted from the Centers for Disease Control Wonder System (http:// wonder.cdc.gov). Average annual age-adjusted region-, race- and gender-specific rates were then calculated.Results: Africa n-American women demonstrated the highest mortality rates for IPAH across all age groups compared to other racial and gender groups. No geographical differences in mortality rates were noted. An increase in mortality rates with advancing age was observed in all racial and gender groups, with the highest mortality rates for IPAH noted in the elderly.Discussion: African Americans with IPAH exhibit a substantially increased mortality compared with Caucasians, particularly African-American women.