Nickel-catalyzed [2+2] Cycloaddition Reaction of Bulky Enones with Simple Alkynes. The Effect of Bulkiness of Substituent Attached at β-Carbon
Nickel-catalyzed [2+2] Cycloaddition Reaction of Bulky Enones with Simple Alkynes. The Effect of Bulkiness of Substituent Attached at β-Carbon
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DOI：
10.1246/cl.130304
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发表时间：
2013-08-05
影响因子：
1.6
通讯作者：
Ogoshi, Sensuke
中科院分区：
文献类型：
--
作者：
Abulimiti, Abudoukadeer;Nishimura, Akira;Ogoshi, Sensuke
在催化量的[Ni（cod）（2）]和PCy_3存在下，β-位带有大取代基的烯酮与简单炔发生[2 + 2]环加成反应，生成环丁烯。β-位上的大体积基团可以抑制烯酮的插入以得到环己烯或烯丙基炔的插入以得到环己二烯。
In the presence of a catalytic amount of [Ni(cod)(2)] and PCy3, the [2 + 2] cycloaddition of enones bearing a bulky substituent group at the beta-position with simple alkynes occurs to give cyclobutenes. The bulky group at the beta-position can suppress the insertion of either an enone to give a cyclohexene or an allcyne to give a cyclohexadiene.