Divergent patterns of breakpoint reuse in Muroid rodents.
Divergent patterns of breakpoint reuse in Muroid rodents.
复制标题
Muroid 啮齿动物中断点重用的不同模式。
DOI：
10.1007/s00335-009-9242-1
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
O'Neill,RJ
中科院分区：
文献类型：
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作者：
Mlynarski,EE;Obergfell,CJ;O'Neill,MJ;O'Neill,RJ
Multiple Genome Rearrangement (MGR) analysis was used to define the trajectory and pattern of chromosome rearrangement within muroid rodents. MGR was applied using 107 chromosome homologies betweenMus,Rattus,Peromyscus, the muroid sister taxonCricetulus griseus, andSciurus carolinensisas a non-Muroidea outgroup, with specific attention paid to breakpoint reuse and centromere evolution. This analysis revealed a high level of chromosome breakpoint conservation betweenRattusandPeromyscusand indicated that the chromosomes ofMusare highly derived. This analysis identified several conserved evolutionary breakpoints that have been reused multiple times during karyotypic evolution in rodents. Our data demonstrate a high level of reuse of breakpoints among muroid rodents, further supporting the “Fragile Breakage Model” of chromosome evolution. We provide the first analysis of rodent centromeres with respect to evolutionary breakpoints. By analyzing closely related rodent species we were able to clarify muroid rodent karyotypic evolution. We were also able to derive several high-resolution ancestral karyotypes and identify rearrangements specific to various stages of Muroidea evolution. These data were useful in further characterizing lineage-specific modes of chromosome evolution.
