Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma.
Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma.
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DOI：
10.2174/156652408785161032
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发表时间：
2008-08
影响因子：
2.5
通讯作者：
Schleimer RP
中科院分区：
文献类型：
--
作者：
Kuperman DA;Schleimer RP
IL-4和IL-13具有许多共同的生物活性。在某种程度上，这是因为它们都通过一个共同的受体发出信号。IL-4Rα。结扎IL-4Rα。结果激活信号转导和激活转录因子6(STAT6)和胰岛素受体底物(IRS)分子。在T细胞和B细胞中，IL-4Rα。信号转导有助于细胞介导和体液方面的过敏性炎症。最近发现，炎症组织中产生的IL-4和IL-13激活了呼吸道正常驻留细胞中的信号。本文的目的是评价IL-4和IL-13诱导的组织反应，特别是STATS介导的组织反应在哮喘一些病理特征中的作用，包括嗜酸性炎症、气道高反应性、上皮下纤维化和粘液过度产生。我们还回顾了最近发现的一些IL-4和/或IL-13诱导的介体的功能，这些介体提供了一些关于分子机制的详细信息，并提出了对宿主防御的重要贡献。
Interleukin (IL)-4 and ll-13 share many biological activities. To some extent, this is because they both signal via a shared receptor. IL-4Rα. Ligation of IL-4Rα. results in activation of Signal Transducer and Activator of Transcription factor 6 (STAT6) and Insulin Receptor Substrate (IRS) molecules. In T- and B-cells, IL-4Rα. signaling contributes to cell-mediated and humoral aspects of allergic inflammation. It has recently become clear that ll-4 and IL-13 produced in inflamed tissues activate signaling in normally resident cells of the airway. The purpose of this review is to critically evaluate the contributions of IL-4- and IL-13-induced tissue responses, especially those mediated by STATS, to some of the pathologic features of asthma including eosinophilic inflammation, airway hyperresponsiveness, subepithelial fibrosis and excessive mucus production. We also review the functions of some recently identified ll-4- and/or IL-13-induced mediators that provide some detail on molecular mechanisms and suggest an important contribution to host defense.