Synthesis and DNA cleaving abilities of functional neocarzinostatin chromophore analogs. Base discrimination by a simple alcohol
Synthesis and DNA cleaving abilities of functional neocarzinostatin chromophore analogs. Base discrimination by a simple alcohol
复制标题
功能性新制癌菌素发色团类似物的合成和 DNA 切割能力。
DOI：
10.1021/ja00026a022
复制
发表时间：
1991
影响因子：
15
通讯作者：
M. Uesugi
中科院分区：
文献类型：
--
作者：
M. Hirama*;T. Gomibuchi;K. Fujiwara;Y. Sugiura;M. Uesugi
糖苷配基、碳水化合物和DNA结合抗生素的插入芳香族部分在位点特异性DNA切割中的精确作用是当前强烈感兴趣的主题。1.2新癌抑制素（NCS）是一种大分子抗肿瘤药物，由具有生物活性的生色团3和作为稳定剂和载体的脱辅基蛋白组成。4.不稳定的二烯二炔分子1同时含有取代的萘甲酸和氨基糖部分，通过产生碳自由基表现出DNA切割活性。5碱基（T> A» C> G）6和序列
The precise roles of aglycon, carbohydrate, and intercalative aromatic moieties of DNA-binding antibiotics in site-specific DNA cleavage is a topic of intense current interest. 1’2 Neocarzinostatin (NCS) is a macromolecular antitumor agent that consists of biologically active chromophorel3 and an apoprotein acting as a stabilizer and a carrier for l. 4 The labile dienediyne molecule 1 equipped with both a substituted naphthoic acid and an amino sugar moiety exhibits DNA-cleaving activities throughcarbon radical generation. 5 The base (T> A» C> G) 6 andsequence