STUDIES IN CUTANEOUS AGING .1. THE ELASTIC FIBER NETWORK
STUDIES IN CUTANEOUS AGING .1. THE ELASTIC FIBER NETWORK
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DOI：
10.1111/1523-1747.ep12507866
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发表时间：
1982-01-01
影响因子：
6.5
通讯作者：
FONFERKO, E
中科院分区：
文献类型：
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作者：
BRAVERMAN, IM;FONFERKO, E
采用光镜和电镜观察了不同年龄银屑病患者和正常人日晒皮肤和防晒皮肤弹性纤维的变化，以区分光化损伤与时间衰老的变化。暴露在阳光下的皮肤出现两种类型的弹性纤维异常，一种与光化损伤有关，另一种与时间老化有关。晒过太阳的臀部皮肤只显示后者。从年龄30-70岁，少数弹性纤维表现出异常，似乎代表纤维解体的过程。70岁以后，大多数弹性纤维出现这些异常。这些异常没有伴随的炎症细胞。此外，形态学证据表明，在这些受试者的一生中，弹性纤维的合成仍在继续，但在50-93岁之间，纤维似乎是松散的，而不是紧密地组装在一起。用猪胰腺弹性蛋白酶和牛胰凝乳蛋白酶孵育青壮年臀部皮肤的真皮切片，产生了弹性纤维降解，这与在老年防晒皮肤中观察到的变化非常相似。皮肤老化的特征之一是弹性纤维固有的缓慢、自发、渐进的降解过程，弹性蛋白酶和凝乳胰蛋白酶可以通过酶促作用将其从几十年加速到几小时。
The elastic fibers in the sun exposed and sun protected skin of normal and psoriatic individuals of different ages was studied by light microscopy and EM to separate the changes of actinic damage from those of chronological aging. The sun exposed skin showed 2 types of elastic fiber abnormalities.sbd.one related to actinic damage and the other to chronological aging. The sun protected buttock skin showed only the latter. From ages 30-70 yr, a minority of the elastic fibers exhibited abnormalities that appeared to represent a process of fiber disintegration. After age 70 yr, the majority of elastic fibers showed these abnormalities. These abnormalities were present without accompanying inflammatory cells. Also, there was morphological evidence of continuing synthesis of elastic fibers during the lifetime of these subjects, except that from ages 50-93 yr, the fibers appeared to be loosely, rather than compactly, assembled. Incubation of dermal slices from buttock skin of young adults with porcine pancreatic elastase and bovine chymotrypsin produced elastic fiber degradation that closely simulated the changes that were observed in aged sun protected skin. One of the features of cutaneous aging is a slow, spontaneous, progressive degradative process inherent in the elastic fiber that can be enzymatically accelerated from decades to hours by elastase and chymotrypsin.