Evaluating prognosis by CK7 differentiating renal cell carcinomas from oncocytomas can be used as a promising tool for optimizing diagnosis strategies.
Evaluating prognosis by CK7 differentiating renal cell carcinomas from oncocytomas can be used as a promising tool for optimizing diagnosis strategies.
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通过 CK7 区分肾细胞癌和嗜酸细胞瘤来评估预后可作为优化诊断策略的有前途的工具。
DOI：
10.18632/oncotarget.10225
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发表时间：
2016-07-19
期刊：
影响因子：
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通讯作者：
Jiang N
中科院分区：
文献类型：
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作者：
Ma F;Dai L;Wang Z;Zhou L;Niu Y;Jiang N
肾嗜酸细胞瘤和肾细胞癌（RCC）具有共同的表型。这使得很难区分这两种肿瘤。在这里，这项研究证实并扩大了CK 7作为一种有前途的工具在不同地理区域区分RCC和Oncocytoma的发现。对数据库进行了系统检索，并确定了其他相关文章。然后根据标准指南对1，711名参与者进行了荟萃分析。根据纳入标准，共纳入21项研究。免疫组化检测CK 7与肾癌诊断率增高显著相关（OR=10.64; 95%CI，7.44-15.23; P=0.0001）。亚组分析显示，当仅考虑白人或亚洲人时，结果没有实质性变化（OR=10.58; 95% CI，6.97-16.07; P<0.01或OR=10.83; 95% CI，5.39-21.74; P=0.004）。也未观察到显著的出版偏倚。我们的研究结果进一步证明了CK 7的表达有助于肾癌与癌细胞瘤的鉴别。CK 7蛋白在肾细胞癌中呈高表达，在所有癌细胞瘤中均呈低表达。CK 7可能是一种重要的肾脏肿瘤标志物。
Renal Oncocytomas and renal cell carcinomas (RCCs) share a common phenotype. This makes it very difficult to differentiate between the two tumors. Here, this study was to confirmed and expanded the findings that CK7 as a promising tool differentiate RCC from Oncocytomas across various geographic regions. A systematic search of databases was carried out and other relevant articles were also identified. Then the meta-analyses were conducted for 1,711 participants according to the standard guidelines. A total of 21 studies were included on the basis of inclusion criteria. CK7 by IHC was significantly associated with increased diagnosis of RCC (OR=10.64; 95% CI, 7.44-15.23; P=0.0001). Subgroup-analysis showed that findings didn't substantially change when only Caucasians or Asians (OR=10.58; 95% CI, 6.97-16.07; P<0.01 or OR=10.83; 95% CI, 5.39-21.74; P=0.004) were considered. There was also no significant publication bias observed. Our findings provide further evidences that the expression of CK7 contribute to differentiate RCC from Oncocytomas. CK7 protein overexpression was found in RCC, low expression in any of Oncocytomas. CK7 is potentially an important renal tumor marker.