The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight.
The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight.
复制标题
分娩时人脐带血清中胰岛素样生长因子-I 和胰岛素样生长因子结合蛋白-1 的浓度：与胎儿体重的关系。
作者：
Hongshun Wang;J. Lim;J. English;L. Irvine;T. Chard
用放射免疫法测定了91例孕妇血液循环、56例脐动脉和90例静脉中胰岛素样生长因子-1 （igf -1）和胰岛素样生长因子结合蛋白-1 （IGFBP-1）的血清水平。脐动脉和脐静脉血清igf - 1浓度与出生体重呈负相关（P < 0.005, P < 0.001）；小胎龄组（SGA）的平均血清IGF-I水平显著高于平均胎龄组（AGA） （P < 0.01和P < 0.001）。然而，母体血清igf - 1与出生体重没有关联，SGA组和AGA组之间没有显著差异。这些观察结果表明，igf - 1在母体和胎儿室的产生是独立的，不太可能通过胎盘转移。母血和脐血（动脉和静脉）血清IGFBP-1水平与出生体重呈负相关（P < 0.001, P < 0.005, P < 0.001）。SGA组脐动脉和静脉IGFBP-1水平升高。这些发现表明，IGFBP-1可能抑制母体和胎儿室中igf -1的作用，IGFBP-1的升高可能是胎儿生长迟缓的主要因素。另外，循环igf -1和IGFBP-1水平可能只是胎儿生长过程中局部组织事件的次要反映。
Serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-1 (IGFBP-1) have been determined by radioimmunoassay in the maternal circulation (n = 91) and in the umbilical artery (n = 56) and vein (n = 90) of man. In both the umbilical artery and vein, the concentration of serum IGF-I showed an inverse correlation with birthweight (P less than 0.005 and P less than 0.001 respectively); the mean serum IGF-I levels in the small-for-gestational-age (SGA) group were significantly higher than those in average-for-gestational-age (AGA) neonates (P less than 0.01 and P less than 0.001 respectively). However, maternal serum IGF-I showed no association with birthweight and there was no significant difference between the SGA and AGA groups. These observations imply that the production of IGF-I in the maternal and fetal compartments is independent and that there is unlikely to be transfer of IGF-I across the placenta. Serum IGFBP-1 levels in both maternal and umbilical cord blood (artery and vein) showed an inverse relation to birthweight (P less than 0.001, P less than 0.005 and P less than 0.001 respectively). Increased IGFBP-1 levels in the umbilical artery and vein were observed in the SGA group. These findings suggest that IGFBP-1 might inhibit the action of IGF-I in both the maternal and the fetal compartments and that the rise in IGFBP-1 could be a primary factor in retardation of fetal growth. Alternatively, circulating IGF-I and IGFBP-1 levels may only be a secondary reflection of local tissue events involved in fetal growth.
胎儿生命期间血清生长调节素-C 循环形式的变化。
DOI：
10.1210/jcem-51-3-674
发表时间：
1980
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
D'Ercole,AJ;Willson,DF;Underwood,LE
通讯作者：
Underwood,LE