Predictors of injection drug use cessation and relapse in a prospective cohort of young injection drug users in San Francisco, CA (UFO Study)
Predictors of injection drug use cessation and relapse in a prospective cohort of young injection drug users in San Francisco, CA (UFO Study)
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DOI：
10.1016/j.drugalcdep.2008.12.007
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发表时间：
2009-05-01
影响因子：
4.2
通讯作者：
Page, Kimberly
中科院分区：
文献类型：
--
作者：
Evans, Jennifer L.;Hahn, Judith A.;Page, Kimberly
背景：注射毒品使用停止的研究主要是在药物治疗环境中对成年人进行抽样。鲜为人知的是，注射停止和复发之间的年轻注射吸毒者（IDU）在Community.Methods：共365 HCV阴性IDU年龄在30岁以下的街道外展招募，每季度进行一次采访，2000年1月至2008年2月之间的前瞻性队列。参与者被随访了638人年和1996次访问。我们使用生存分析技术，以确定相关的注射停止（3个月）和复发到inject.Results：67%的受试者是男性，中位年龄为22岁（四分位数范围（IQR）20-26）和中位年注射为3.6（IQR 1.3-6.5）。28.8%的人在随访期间停止注射。在那些停止注射的人中，近一半在随后的访问中恢复了药物注射，四分之一保持注射停止，四分之一失访。在过去3个月内参加药物治疗计划和每月注射少于30次与注射停止有关。注射海洛因或海洛因与其他药物混合，注射以前使用的药物制备设备的残留物，饮酒，使用苯二氮卓类药物与戒烟呈负相关。年轻的年龄与复发injection.Conclusion：这些结果表明，与停止注射相关的因素涉及多个领域的干预，包括获得药物治疗和行为方法，以减少注射和维持停止。该队列中年轻受试者的复发率较高，强调了针对青少年和过渡年龄青年的早期检测和治疗计划的必要性。(C)出版社：Elsevier爱尔兰Ltd.
Background: Studies of injection drug use cessation have largely sampled adults in drug treatment settings. Little is known about injection cessation and relapse among young injection drug users (IDU) in the Community.Methods: A total of 365 HCV-negative IDU under age 30 years were recruited by street outreach and interviewed quarterly for a prospective cohort between January 2000 and February 2008. Participants were followed for a total of 638 person-years and 1996 visits. We used survival analysis techniques to identify correlates of injection cessation (3 months) and relapse to injection.Results: 67% of subjects were male, median age was 22 years (interquartile range (IQR) 20-26) and median years injecting was 3.6 (IQR 1.3-6.5). 28.8% ceased injecting during the follow-up period. Among those that ceased injecting, nearly one-half resumed drug injection on subsequent visits, one-quarter maintained injecting cessation, and one-quarter were lost to follow-up. Participating in a drug treatment program in the last 3 months and injecting less than 30 times per month were associated with injection cessation. Injecting heroin or heroin mixed with other drugs, injecting the residue from previously used drug preparation equipment, drinking alcohol, and using benzodiazepines were negatively associated with cessation. Younger age was associated with relapse to injection.Conclusion: These results suggest that factors associated with stopping injecting involve multiple areas of intervention, including access to drug treatment and behavioral approaches to reduce injection and sustain cessation. The higher incidence of relapse in the younger subjects in this cohort underscores the need for earlier detection and treatment programs targeted to adolescents and transition-age youth. (C) Published by Elsevier Ireland Ltd.