Ghrelin modulates brain activity in areas that control appetitive behavior
Ghrelin modulates brain activity in areas that control appetitive behavior
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DOI：
10.1016/j.cmet.2008.03.007
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发表时间：
2008-05-01
期刊：
影响因子：
29
通讯作者：
Dagher, Alain
中科院分区：
文献类型：
--
作者：
Malik, Saima;McGlone, Francis;Dagher, Alain
摄食行为通常分为自我平衡和享乐两部分。视觉或嗅觉食物线索可以触发享乐喂养，涉及在奖励和动机中发挥作用的大脑区域，而稳态喂养被认为是在主要作用于下丘脑的循环激素的控制下。Ghrelin是一种由肠道分泌的肽类激素，可引起饥饿和食物消耗。在这里，我们表明，在功能性磁共振成像过程中静脉注射给健康志愿者的ghrelin增加了大脑区域对食物图片的神经反应，包括杏仁核，眶额皮质，前额叶和纹状体，涉及编码食物线索的激励价值。饥饿素对杏仁核和眶额皮层反应的影响与自我评定的饥饿等级相关。这表明，代谢信号，如生长激素释放肽可能有利于食物消费，通过增强享乐和刺激反应的食物相关的线索。
Feeding behavior is often separated into homeostatic and hedonic components. Hedonic feeding, which can be triggered by visual or olfactory food cues, involves brain regions that play a role in reward and motivation, while homeostatic feeding is thought to be under the control of circulating hormones acting primarily on the hypothalamus. Ghrelin is a peptide hormone secreted by the gut that causes hunger and food consumption. Here, we show that ghrelin administered intravenously to healthy volunteers during functional magnetic resonance imaging increased the neural response to food pictures in regions of the brain, including the amygdala, orbitofrontal cortex, anterior insula, and striatum, implicated in encoding the incentive value of food cues. The effects of ghrelin on the amygdala and OFC response were correlated with self-rated hunger ratings. This demonstrates that metabolic signals such as ghrelin may favor food consumption by enhancing the hedonic and incentive responses to food-related cues.