Halothane is less suppressive than pentobarbital on reflex and neural activation of pancreatic F-cell.
Halothane is less suppressive than pentobarbital on reflex and neural activation of pancreatic F-cell.
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氟烷对胰腺 F 细胞的反射和神经激活的抑制作用低于戊巴比妥。
DOI：
10.1152/ajpendo.1986.251.1.e111
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
TaborskyJr,GJ
中科院分区：
文献类型：
--
作者：
Havel,PJ;Paquette,TL;TaborskyJr,GJ
为了确定氟烷麻醉对犬内分泌胰腺副交感神经控制研究的适用性，我们评估了氟烷对胰岛副交感神经输入的反射、直接神经和直接化学激活的影响。胰多肽（PP）（一种主要受胆碱能影响的胰岛激素）的水平或输出量被用作副交感神经激活程度及其受麻醉潜在抑制的指标。在用氟烷（0.8%）麻醉的犬中，2-脱氧-D-葡萄糖（2-DG）对副交感神经系统的反射刺激导致血浆PP水平增加4倍，相当于清醒犬的反应。相比之下，2-DG在此剂量和在三倍更高的剂量没有改变PP水平的狗麻醉与戊巴比妥（30毫克/公斤静脉注射），这表明氟烷在此剂量是没有抑制和戊巴比妥是非常抑制的副交感神经的反射激活胰腺。在氟烷麻醉的狗的颈部迷走神经的双侧电刺激引起PP的胰腺输出的六倍增加。同样的刺激只引起了2倍的戊巴比妥麻醉犬的PP输出增加。这些数据表明，氟烷对外周神经传递或胰腺F细胞反应性的抑制作用也低于戊巴比妥。氨甲酰甲胆碱直接激活F细胞的效果在两种麻醉剂之间没有差异。因此，戊巴比妥麻醉犬对迷走神经刺激的PP反应减弱可能是由于戊巴比妥对外周神经传递的作用，可能是在胰腺内副交感神经节。（250字处删节）
To determine the suitability of halothane anesthesia for studies of parasympathetic control of the endocrine pancreas in dogs, we assessed the effect of halothane on reflex, direct neural, and direct chemical activation of the parasympathetic input to the islet. Levels or output of pancreatic polypeptide (PP), an islet hormone under predominant cholinergic influence, were used as an indicator of the degree of parasympathetic activation and its potential suppression by anesthesia. Reflex stimulation of the parasympathetic nervous system by 2-deoxy-D-glucose (2-DG) in dogs anesthetized with halothane (0.8%) caused a fourfold increase in plasma PP levels, equivalent to the response in conscious dogs. In contrast, 2-DG at this dose and at a threefold higher dose did not alter PP levels in dogs anesthetized with pentobarbital (30 mg/kg iv), suggesting that halothane at this dose is not suppressive and that pentobarbital is very suppressive on reflex activation of the parasympathetic nerves to the pancreas. Bilateral electrical stimulation of the cervical vagi in halothane-anesthetized dogs elicited a sixfold increase in the pancreatic output of PP. The same stimulation caused only a twofold increase of PP output in pentobarbital-anesthetized dogs. These data suggests that halothane is also less inhibitory than pentobarbital on either peripheral neurotransmission or pancreatic F-cell responsiveness. The effect of direct activation of the F-cell by bethanechol did not differ between the two anesthesias. Therefore, the attenuated PP response to vagal stimulation in pentobarbital-anesthetized dogs is probably due to an action of pentobarbital on peripheral neurotransmission, perhaps at the intrapancreatic parasympathetic ganglia.(ABSTRACT TRUNCATED AT 250 WORDS)