Pestaloquinols A and B, Isoprenylated Epoxyquinols from Pestalotiopsis sp.
Pestaloquinols A and B, Isoprenylated Epoxyquinols from Pestalotiopsis sp.
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DOI：
10.1021/np100723t
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发表时间：
2011-02-01
影响因子：
5.1
通讯作者：
Che, Yongsheng
中科院分区：
文献类型：
--
作者：
Ding, Gang;Zhang, Fan;Che, Yongsheng
从植物内生真菌拟盘多毛孢（Pestalotiopsis sp.）的粗提物中分离得到两个新的异戊二烯化环氧喹啉衍生物，pestaloquinols A（2）和B（3），以及它们的生物合成前体细胞菌素D（1）。培他醌醇A（2）和B（3）具有以前未描述的九环系统，并显示出对HeLa细胞的细胞毒性。
Two new isoprenylated epoxyquinol derivatives, pestaloquinols A (2) and B (3), and their putative biosynthetic precursor, cytosporin D (1), were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis sp. The structures of these compounds were elucidated primarily by NMR experiments. Pestaloquinols A (2) and B (3) possess a previously undescribed nonacyclic ring system and showed cytotoxicity against HeLa cells.