Models of chronic kidney disease.
Models of chronic kidney disease.
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DOI：
10.1016/j.ddmod.2010.08.002
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Fogo, Agnes B
中科院分区：
文献类型：
--
作者：
Yang, Hai-Chun;Zuo, Yiqin;Fogo, Agnes B
慢性肾脏疾病是由肾小球、肾小管、肾小球和/或脉管系统的反复或进行性损伤引起的。为了研究发病机制、干预机制和干预效果，人们建立了许多动物模型，包括自发性、遗传性和诱导性模型。然而，这些模型并不能准确地模拟人类疾病，而且大多数模型都依赖于菌株、性别或年龄。我们回顾了慢性肾脏疾病的各种啮齿动物模型的关键信息。
Chronic kidney diseases result from recurrent or progressive injuries in glomeruli, tubules, interstitium and/or vasculature. In order to study pathogenesis, mechanisms and effects of interventions, many animal models have been developed, including spontaneous, genetic and induced models. However, these models do not exactly simulate human diseases, and most of them are strain, gender or age dependent. We review key information on various rodent models of chronic kidney diseases.